Association of lifestyle related factors and psoriatic arthritis

[Fred]

Does your lifestyle affect your psoriatic arthritis (PsA) ? this study looked at the latest research.

Quote:

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Objective:
This study aims to investigate lifestyle-related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements.

Methods:
This multicenter cohort included 938 patients newly diagnosed with PsA, between 2013 and 2023. A composite lifestyle risk score (range 0 to 5) was calculated using five lifestyle-related factors assessed at baseline (BMI outside normal range, abdominal obesity, current smoking, no alcohol consumption, physical inactivity). Higher scores indicate the presence of more lifestyle-related risk factors. One year disease activity outcomes included PsA Disease Activity Score (PASDAS), disease activity in PsA (DAPSA), PASDAS and DAPSA low disease activity (LDA) and remission, and minimal disease activity (MDA).

Results:
The rate of obesity was 33%, abdominal obesity was 51%, current smoking was 19%, and alcohol consumption was 72% with 3% of patients physically inactive. Using multivariable analyses, a higher lifestyle risk score was associated with higher PASDAS (β 0.15; 95%CI 0.08, 0.23), and lower odds for achieving PASDAS-LDA (OR 0.59; 95%CI 0.45, 0.77), and MDA (OR 0.72; 95%CI 0.57, 0.90) at one year follow-up. Similar associations were observed for DAPSA (βadj 1.18; 95%CI 0.65, 1.71) and DAPSA-LDA (OR 0.74; 95%CI 0.59, 0.92). Analysis of individual factors showed that general obesity, abdominal obesity and smoking, were significantly associated with higher PASDAS and DAPSA, and lower odds for achieving PASDAS-LDA and MDA.

Conclusion:
Lifestyle-related risk factors were prevalent in patients with PsA. The associations between lifestyle-related factors and PsA disease activity, mainly obesity and smoking, provide foundation to address lifestyle in PsA care.

Source: onlinelibrary.wiley.com

*Funding: Early view funding unknown.

[Caroline]

Interesting and to be expected.

But on the other side, when I got my Psoriatic Arthritis I was superslim, with a more than excellent BMI. And I have never smoked.

So this is only part of the story.

[Waine]

Two things I don't understand.

1 - Why is alcohol the highest percentage score, but then not mentioned as one of the factors.

2 - What about stress? I guess because it isn't as easy as measuring the other factors, but then people are self-reporting smoking, alcohol and activity so it is reliant on anecdotal data anyway. 

I found alcohol and weight to be almost inversely correlated with my PsA (the more weight I lost and giving alcohol seemed (emphasis - correlation isn't causation) to have no impact, but stress definitely triggers a flare. And I don't knowingly stress eat, and weight doesn't go up, and don't drink when I get stressed out.

[Caroline]

Two things I don't understand.

1 - Why is alcohol the highest percentage score, but then not mentioned as one of the factors.

2 - What about stress? I guess because it isn't as easy as measuring the other factors, but then people are self-reporting smoking, alcohol and activity so it is reliant on anecdotal data anyway. 

I found alcohol and weight to be almost inversely correlated with my PsA (the more weight I lost and giving alcohol seemed (emphasis - correlation isn't causation) to have no impact, but stress definitely triggers a flare. And I don't knowingly stress eat, and weight doesn't go up, and don't drink when I get stressed out.

Very good points Waine.

1. For me the removal of alcohol was significant.

2. And indeed, stress is a very strong factor.

[glenda grant]

Two things I don't understand.

1 - Why is alcohol the highest percentage score, but then not mentioned as one of the factors.

2 - What about stress? I guess because it isn't as easy as measuring the other factors, but then people are self-reporting smoking, alcohol and activity so it is reliant on anecdotal data anyway. 

I found alcohol and weight to be almost inversely correlated with my PsA (the more weight I lost and giving alcohol seemed (emphasis - correlation isn't causation) to have no impact, but stress definitely triggers a flare. And I don't knowingly stress eat, and weight doesn't go up, and don't drink when I get stressed out.

Very good points Waine.

1. For me the removal of alcohol was significant.

2. And indeed, stress is a very strong factor.

I never drank, smoked I am a little chubby i don't like the word fat lol would you believe i have Cirrhosis now stress i have a lot of that. I think we all have stress in our life just to much on our minds. someone once told me I need to relax I told them I can't I have been hyper active all my life but it seems like my body is slowing down and it's hard to cope with. I need to start enjoying life before it's too late.I take SKYRIZI that has helped me immensely but the Psoriatic Arthritis not much help. But I see a new Rheumatologist now and she is trying to work with me with a new medication. She is taking liver counts on me.Hopefully the pill will help me.

[Waine]

  I never drank, smoked I am a little chubby i don't like the word fat lol would you believe i have Cirrhosis now stress i have a lot of that. I think we all have stress in our life just to much on our minds. someone once told me I need to relax I told them I can't I have been hyper active all my life but it seems like my body is slowing down and it's hard to cope with. I need to start enjoying life before it's too late.I take SKYRIZI  that has helped me immensely but the Psoriatic Arthritis not much help. But I see a new Rheumatologist now and she is trying to work with me with a new medication. She is taking liver counts on me.Hopefully the pill will help me.

That's curious, getting Cirrhosis without drinking. 

We all have stress, but I sometimes get that thing that makes your stomach churn, and for me makes me occasionally vomit. It has been demonstrated that excess Cortisol, or the inability to process it quickly, kills gut bacteria and causes that queasy feeling. Of course too much Cortisol cause inflammation as well. As being told to relax.....nothing stresses me out more than that ! 

[Caroline]

  I never drank, smoked I am a little chubby i don't like the word fat lol would you believe i have Cirrhosis now stress i have a lot of that. I think we all have stress in our life just to much on our minds. someone once told me I need to relax I told them I can't I have been hyper active all my life but it seems like my body is slowing down and it's hard to cope with. I need to start enjoying life before it's too late.I take SKYRIZI  that has helped me immensely but the Psoriatic Arthritis not much help. But I see a new Rheumatologist now and she is trying to work with me with a new medication. She is taking liver counts on me.Hopefully the pill will help me.

That's curious, getting Cirrhosis without drinking. 

We all have stress, but I sometimes get that thing that makes your stomach churn, and for me makes me occasionally vomit. It has been demonstrated that excess Cortisol, or the inability to process it quickly, kills gut bacteria and causes that queasy feeling. Of course too much Cortisol cause inflammation as well. As being told to relax.....nothing stresses me out more than that ! 

Yess… that is the elephant effect.
I someone says to you: “Don’t think of a pink elephant!”, the first thing in your mind will be a pink elephant.